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| Attribute | Neuroprotective ARA-290 |
|---|---|
| Summary | EPO-derived peptide for small-fiber neuropathy and inflammatory nerve pain. |
| Mechanism | 11-amino-acid peptide derived from erythropoietin. Activates the innate-repair receptor (IRR) without erythropoietic effects — anti-inflammatory and neuroprotective. |
| Top outcomes |
|
| Evidence | emerging |
| Half-life | ~2 minutes (active signaling persists longer) |
| Administration | subq |
| Legal status | research only |
| Safety | Well tolerated in trials, including no measurable change to hematocrit at therapeutic doses. |