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Exenatide
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Peptide
GLP-1 Agonist
ExenatideOverview
Summary
The original GLP-1 agonist — clinically displaced by newer agents but still in use.
Category
GLP-1 Agonist
Mechanism
Synthetic analog of exendin-4 (Gila monster saliva) — first-in-class GLP-1.
Effects
Top outcomes
- Fat loss65
Evidence
Established
Practical
Half-life
~2.4 hours / 7 days (LAR)
Administration
subq
Risk
Legal status
rx only
Safety
Nausea, pancreatitis warning, antibody formation at higher rates than newer GLP-1s.
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