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| Attribute | GLP-1 Agonist Exenatide |
|---|---|
| Summary | The original GLP-1 agonist — clinically displaced by newer agents but still in use. |
| Mechanism | Synthetic analog of exendin-4 (Gila monster saliva) — first-in-class GLP-1. |
| Top outcomes |
|
| Evidence | established |
| Half-life | ~2.4 hours / 7 days (LAR) |
| Administration | subq |
| Legal status | rx only |
| Safety | Nausea, pancreatitis warning, antibody formation at higher rates than newer GLP-1s. |