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Retatrutide
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Peptide
GLP-1 / GIP / Glucagon Triple Agonist
Retatrutide
Overview
Summary
Investigational triple-agonist with the largest weight-loss numbers in early trials.
Category
GLP-1 / GIP / Glucagon Triple Agonist
Mechanism
Triple-agonist targeting GLP-1, GIP, and glucagon receptors for additive metabolic effect.
Effects
Top outcomes
  • Fat loss97
Evidence
Emerging
Practical
Half-life
~6 days (estimated)
Administration
subq
Risk
Legal status
research only
Safety
Side-effect profile similar to other GLP-class drugs; long-term data pending.
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