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| Attribute | Monoamine Reuptake Inhibitor Tesofensine |
|---|---|
| Summary | Non-peptide oral weight-loss agent with strong Phase 2 data. |
| Mechanism | Triple reuptake inhibitor of noradrenaline, dopamine and serotonin. |
| Top outcomes |
|
| Evidence | emerging |
| Half-life | ~9 days |
| Administration | oral |
| Legal status | research only |
| Safety | Blood pressure and heart rate increases; insomnia; mood effects. |