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| Attribute | Melanocortin Melanotan I |
|---|---|
| Summary | The first-generation tanning peptide. More selective than Melanotan II, with a cleaner side-effect profile. |
| Mechanism | Selective α-MSH analog at the MC1R receptor, stimulating eumelanin synthesis in melanocytes for UV-protective pigmentation. |
| Top outcomes |
|
| Evidence | established |
| Half-life | ~30 minutes (parent); pigmentation persists weeks |
| Administration | subq |
| Legal status | approved some regions |
| Safety | Generally well tolerated. Monitor moles for change — any melanocortin agonist can stimulate existing nevi. |