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Melanotan I
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Peptide
Melanocortin
Melanotan I
Overview
Summary
The first-generation tanning peptide. More selective than Melanotan II, with a cleaner side-effect profile.
Category
Melanocortin
Mechanism
Selective α-MSH analog at the MC1R receptor, stimulating eumelanin synthesis in melanocytes for UV-protective pigmentation.
Effects
Top outcomes
  • Tan90
  • Glow55
Evidence
Established
Practical
Half-life
~30 minutes (parent); pigmentation persists weeks
Administration
subq
Risk
Legal status
approved some regions
Safety
Generally well tolerated. Monitor moles for change — any melanocortin agonist can stimulate existing nevi.
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