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Orforglipron
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Peptide
Oral GLP-1
OrforglipronOverview
Summary
Oral GLP-1 with no food/water restrictions — the convenience play.
Category
Oral GLP-1
Mechanism
Small-molecule non-peptide GLP-1 agonist — first oral once-daily option without dietary restrictions.
Effects
Top outcomes
- Fat loss85
Evidence
Emerging
Practical
Half-life
~29-49 hours
Administration
oral
Risk
Legal status
research only
Safety
GI side effects on titration; long-term safety pending.
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