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| Attribute | Oral GLP-1 Orforglipron |
|---|---|
| Summary | Oral GLP-1 with no food/water restrictions — the convenience play. |
| Mechanism | Small-molecule non-peptide GLP-1 agonist — first oral once-daily option without dietary restrictions. |
| Top outcomes |
|
| Evidence | emerging |
| Half-life | ~29-49 hours |
| Administration | oral |
| Legal status | research only |
| Safety | GI side effects on titration; long-term safety pending. |