PepVault
/ database / Oral GLP-1

Orforglipron

Also: LY-3502970

Oral GLP-1 with no food/water restrictions — the convenience play.

Evidence
emerging
Legal status
research only
Half-life
~29-49 hours
Routes
oral
View on Limitless LifeAdd to compare
What it is

Unlike oral semaglutide, orforglipron is a small molecule, not a peptide, so it doesn't need rigorous fasting protocols. Phase 2 data showed ~14.7% weight loss over 36 weeks.

Mechanism

Small-molecule non-peptide GLP-1 agonist — first oral once-daily option without dietary restrictions.

Outcomes it's matched to
Safety

GI side effects on titration; long-term safety pending.

  • Pregnancy
  • Personal/family MTC
Legal context

Not approved. Phase 3 ongoing (Eli Lilly).

1:1 GUIDANCE

Have questions about this peptide?

Get free 1:1 guidance from a peptide professional before you start. They'll help you think through dosing, stacking, and whether this fits your goals.

REQUEST A CALL →
PepVault

An outcome-driven reference for modern peptides. Educational only — not medical advice, not a sales platform, not affiliated with any clinic.

Disclaimer: PepVault is an educational resource. Nothing on this site is medical advice. Many peptides discussed are research compounds and are not approved by the FDA or equivalent agencies. Always consult a qualified clinician before starting any protocol.

© 2026 PepVault