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Orforglipron

Also: LY-3502970

Oral GLP-1 with no food/water restrictions — the convenience play.

Evidence
emerging
Legal status
research only
Half-life
~29-49 hours
Routes
oral
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What it is

Unlike oral semaglutide, orforglipron is a small molecule, not a peptide, so it doesn't need rigorous fasting protocols. Phase 2 data showed ~14.7% weight loss over 36 weeks.

Mechanism

Small-molecule non-peptide GLP-1 agonist — first oral once-daily option without dietary restrictions.

Outcomes it's matched to
Safety

GI side effects on titration; long-term safety pending.

  • Pregnancy
  • Personal/family MTC
Legal context

Not approved. Phase 3 ongoing (Eli Lilly).

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