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| Attribute | Melanocortin Agonist PT-141 |
|---|---|
| Summary | Centrally-acting libido peptide — FDA-approved for premenopausal HSDD. |
| Mechanism | MC4R agonist that acts centrally on sexual desire pathways, independently of vascular flow. |
| Top outcomes |
|
| Evidence | established |
| Half-life | ~2 hours |
| Administration | subq, nasal |
| Legal status | rx only |
| Safety | Nausea, flushing, and transient blood-pressure increase reported. |