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PT-141

Also: Bremelanotide · Vyleesi

Centrally-acting libido peptide — FDA-approved for premenopausal HSDD.

Evidence
established
Legal status
rx only
Half-life
~2 hours
Routes
subq · nasal
US-sourcedHPLC testedLot-traceableView this lot's COA →
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What it is

PT-141 is approved (as Vyleesi) for hypoactive sexual desire disorder in premenopausal women. Unlike PDE5 inhibitors, it works centrally on desire rather than peripherally on vascular flow. Used off-label by both sexes.

Mechanism

MC4R agonist that acts centrally on sexual desire pathways, independently of vascular flow.

Outcomes it's matched to
Safety

Nausea, flushing, and transient blood-pressure increase reported.

  • Uncontrolled hypertension
  • Cardiovascular disease
Legal context

Prescription medication.

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