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| Attribute | GLP-1 Agonist Semaglutide |
|---|---|
| Summary | The category-defining GLP-1 for weight loss and metabolic health. |
| Mechanism | Long-acting GLP-1 receptor agonist. Slows gastric emptying, suppresses appetite, and improves glycemic control. |
| Top outcomes |
|
| Evidence | established |
| Half-life | ~7 days |
| Administration | subq, oral |
| Legal status | rx only |
| Safety | GI side effects (nausea, constipation) common. Lean-mass loss possible without resistance training. |