PepVault
/ database / GLP-1 Agonist

Semaglutide

Also: Ozempic · Wegovy · Rybelsus

The category-defining GLP-1 for weight loss and metabolic health.

Evidence
established
Legal status
rx only
Half-life
~7 days
Routes
subq · oral
View on Limitless LifeAdd to compare
What it is

Semaglutide is a long-acting GLP-1 agonist that has rewritten the playbook for weight management. It reduces appetite, slows gastric emptying, and produces durable weight loss across multiple large clinical trials.

Mechanism

Long-acting GLP-1 receptor agonist. Slows gastric emptying, suppresses appetite, and improves glycemic control.

Outcomes it's matched to
Safety

GI side effects (nausea, constipation) common. Lean-mass loss possible without resistance training.

  • Personal or family history of medullary thyroid carcinoma
  • MEN-2 syndrome
  • Pregnancy
Legal context

Prescription medication. Many countries require physician oversight.

1:1 GUIDANCE

Have questions about this peptide?

Get free 1:1 guidance from a peptide professional before you start. They'll help you think through dosing, stacking, and whether this fits your goals.

REQUEST A CALL →
PepVault

An outcome-driven reference for modern peptides. Educational only — not medical advice, not a sales platform, not affiliated with any clinic.

Disclaimer: PepVault is an educational resource. Nothing on this site is medical advice. Many peptides discussed are research compounds and are not approved by the FDA or equivalent agencies. Always consult a qualified clinician before starting any protocol.

© 2026 PepVault