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| Attribute | Growth Hormone Releasing Hormone Analog Tesamorelin | Metabolic AOD-9604 | Metabolic 5-Amino-1MQ |
|---|---|---|---|
| Summary | The visceral-fat peptide — FDA-approved for HIV-associated lipodystrophy. | GH-fragment with lipolytic action and no growth signaling. | NNMT inhibitor for fat loss and metabolic health. |
| Mechanism | A stabilized GHRH analog. Selectively reduces visceral adipose tissue in studied populations. | Modified C-terminal fragment of GH. Promotes lipolysis without affecting IGF-1. | NNMT inhibitor. Preserves NAD+ and SAM, supporting metabolism and adipocyte function. |
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| Evidence | established | emerging | anecdotal |
| Half-life | ~26 min (peptide), but downstream GH effect lasts hours | Short | Several hours (oral) |
| Administration | subq | subq | oral |
| Legal status | rx only | research only | research only |
| Safety | Generally well tolerated; injection-site reactions most common. | Well tolerated in trials; efficacy modest. | Limited human data. |