Ipamorelin
Also: Ipa
Clean GH pulse — widely used for sleep, recovery, and lean composition.
Evidence
emerging
Legal status
research only
Half-life
~2 hours
Routes
subq
What it is
Ipamorelin is prized for being one of the cleanest growth-hormone secretagogues, with minimal effect on cortisol, prolactin, or appetite. It produces a short, sharp GH pulse — most commonly dosed before sleep to amplify the natural nighttime release.
Mechanism
Selective ghrelin receptor agonist that triggers a clean, pulsatile GH release without strongly affecting cortisol or prolactin.
Outcomes it's matched to
- STRENGTH80%
- STRENGTH78%
- STRENGTH72%
- STRENGTH60%
Safety
Generally well tolerated; mild head-rush or hunger reported by some users.
- Active cancer
- Pregnancy
Legal context
Not FDA-approved. Research-use only in the US.