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Semax

Also: ACTH(4-10) analog

Russian nootropic for focus and neuroprotection.

Evidence
emerging
Legal status
research only
Half-life
Short (nasal action)
Routes
nasal
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What it is

Semax is a heptapeptide developed in Russia and used clinically there for stroke and cognitive indications. It strongly upregulates BDNF and is favored for focused work blocks.

Mechanism

ACTH(4-10) analog. Upregulates BDNF and modulates dopamine.

Outcomes it's matched to
  • Cognition

    Cognition & Focus

    Robust BDNF upregulation and dopamine modulation.

    STRENGTH
    82%
Safety

Well tolerated; rare mild nasal irritation.

  • Pregnancy
  • Psychiatric instability
Legal context

Approved in Russia for stroke recovery; research-only elsewhere.

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