/ database / Longevity

NAD+

Also: Nicotinamide Adenine Dinucleotide

Cofactor for mitochondrial energy and sirtuin-mediated longevity pathways.

Evidence
emerging
Legal status
approved some regions
Half-life
Varies by route
Routes
subq · im
What it is

NAD+ levels decline with age. Direct injection or IV infusion is used to raise tissue NAD+, supporting energy production and DNA repair pathways. Oral precursors (NR, NMN) are more common but less direct.

Mechanism

Coenzyme essential for cellular energy production and sirtuin activity. Direct infusion or injection raises tissue levels.

Outcomes it's matched to
Safety

Injection can be uncomfortable (flushing, pressure). IV is well tolerated when titrated.

  • Active malignancy (theoretical)
Legal context

Available via specialty pharmacies and IV clinics.

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