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EpitalonMOTS-cNAD+SS-31Thymosin Alpha-1
5 / 4
Peptide
Longevity
EpitalonMitochondrial
MOTS-cLongevity
NAD+Mitochondrial
SS-31Immune Modulation
Thymosin Alpha-1Overview
Summary
Pineal-derived longevity peptide with proposed telomerase effects.
Mitochondrial peptide for metabolic flexibility and exercise capacity.
Cofactor for mitochondrial energy and sirtuin-mediated longevity pathways.
Mitochondrial targeting peptide studied for energy and age-related decline.
Immune modulator — used clinically for chronic viral infections and immune support.
Category
Longevity
Mitochondrial
Longevity
Mitochondrial
Immune Modulation
Mechanism
Tetrapeptide derived from pineal extract. Proposed to upregulate telomerase activity.
Mitochondrial-derived peptide. Activates AMPK, improves insulin sensitivity and mitochondrial function.
Coenzyme essential for cellular energy production and sirtuin activity. Direct infusion or injection raises tissue levels.
Targets cardiolipin in the inner mitochondrial membrane, stabilizing ATP production.
28-amino-acid peptide that modulates T-cell maturation and immune balance.
Effects
Top outcomes
- Longevity78
- Sleep55
- Energy80
- Longevity70
- Fat loss60
- Energy78
- Longevity72
- Cognition55
- Energy78
- Longevity65
- Inflammation70
- Recovery60
- Longevity55
Evidence
Anecdotal
Emerging
Emerging
Emerging
Established
Practical
Half-life
~30 min (short; cycled dosing typical)
Several hours
Varies by route
~2-3 hours
~2 hours
Administration
subq
subq
subqim
subq
subq
Risk
Legal status
research only
research only
approved some regions
research only
approved some regions
Safety
No major adverse events reported in available literature.
Limited human safety data; well tolerated anecdotally.
Injection can be uncomfortable (flushing, pressure). IV is well tolerated when titrated.
Well tolerated in trials.
Very well tolerated. Mild injection-site reactions most common.
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