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MOTS-c

Also: Mitochondrial ORF of 12S rRNA-c

Mitochondrial peptide for metabolic flexibility and exercise capacity.

Evidence
emerging
Legal status
research only
Half-life
Several hours
Routes
subq
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What it is

MOTS-c is encoded in the mitochondrial genome and signals via AMPK. Animal studies show improved insulin sensitivity, exercise capacity, and resistance to age-related metabolic decline.

Mechanism

Mitochondrial-derived peptide. Activates AMPK, improves insulin sensitivity and mitochondrial function.

Outcomes it's matched to
Safety

Limited human safety data; well tolerated anecdotally.

  • Pregnancy
Legal context

Not approved. Research-use only.

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