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| Attribute | Longevity Epitalon | Mitochondrial MOTS-c | Immune Modulation Thymosin Alpha-1 | Longevity NAD+ |
|---|---|---|---|---|
| Summary | Pineal-derived longevity peptide with proposed telomerase effects. | Mitochondrial peptide for metabolic flexibility and exercise capacity. | Immune modulator — used clinically for chronic viral infections and immune support. | Cofactor for mitochondrial energy and sirtuin-mediated longevity pathways. |
| Mechanism | Tetrapeptide derived from pineal extract. Proposed to upregulate telomerase activity. | Mitochondrial-derived peptide. Activates AMPK, improves insulin sensitivity and mitochondrial function. | 28-amino-acid peptide that modulates T-cell maturation and immune balance. | Coenzyme essential for cellular energy production and sirtuin activity. Direct infusion or injection raises tissue levels. |
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| Evidence | anecdotal | emerging | established | emerging |
| Half-life | ~30 min (short; cycled dosing typical) | Several hours | ~2 hours | Varies by route |
| Administration | subq | subq | subq | subq, im |
| Legal status | research only | research only | approved some regions | approved some regions |
| Safety | No major adverse events reported in available literature. | Limited human safety data; well tolerated anecdotally. | Very well tolerated. Mild injection-site reactions most common. | Injection can be uncomfortable (flushing, pressure). IV is well tolerated when titrated. |