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EpitalonThymosin Alpha-1MOTS-cSS-31NAD+
5 / 4
Peptide
Longevity
Epitalon
Immune Modulation
Thymosin Alpha-1
Mitochondrial
MOTS-c
Mitochondrial
SS-31
Longevity
NAD+
Overview
Summary
Pineal-derived longevity peptide with proposed telomerase effects.
Immune modulator — used clinically for chronic viral infections and immune support.
Mitochondrial peptide for metabolic flexibility and exercise capacity.
Mitochondrial targeting peptide studied for energy and age-related decline.
Cofactor for mitochondrial energy and sirtuin-mediated longevity pathways.
Category
Longevity
Immune Modulation
Mitochondrial
Mitochondrial
Longevity
Mechanism
Tetrapeptide derived from pineal extract. Proposed to upregulate telomerase activity.
28-amino-acid peptide that modulates T-cell maturation and immune balance.
Mitochondrial-derived peptide. Activates AMPK, improves insulin sensitivity and mitochondrial function.
Targets cardiolipin in the inner mitochondrial membrane, stabilizing ATP production.
Coenzyme essential for cellular energy production and sirtuin activity. Direct infusion or injection raises tissue levels.
Effects
Top outcomes
  • Longevity78
  • Sleep55
  • Inflammation70
  • Recovery60
  • Longevity55
  • Energy80
  • Longevity70
  • Fat loss60
  • Energy78
  • Longevity65
  • Energy78
  • Longevity72
  • Cognition55
Evidence
Anecdotal
Established
Emerging
Emerging
Emerging
Practical
Half-life
~30 min (short; cycled dosing typical)
~2 hours
Several hours
~2-3 hours
Varies by route
Administration
subq
subq
subq
subq
subqim
Risk
Legal status
research only
approved some regions
research only
research only
approved some regions
Safety
No major adverse events reported in available literature.
Very well tolerated. Mild injection-site reactions most common.
Limited human safety data; well tolerated anecdotally.
Well tolerated in trials.
Injection can be uncomfortable (flushing, pressure). IV is well tolerated when titrated.
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