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Attribute
Longevity
Epitalon
Immune Modulation
Thymosin Alpha-1
Mitochondrial
MOTS-c
Mitochondrial
SS-31
Longevity
NAD+
SummaryPineal-derived longevity peptide with proposed telomerase effects.Immune modulator — used clinically for chronic viral infections and immune support.Mitochondrial peptide for metabolic flexibility and exercise capacity.Mitochondrial targeting peptide studied for energy and age-related decline.Cofactor for mitochondrial energy and sirtuin-mediated longevity pathways.
MechanismTetrapeptide derived from pineal extract. Proposed to upregulate telomerase activity.28-amino-acid peptide that modulates T-cell maturation and immune balance.Mitochondrial-derived peptide. Activates AMPK, improves insulin sensitivity and mitochondrial function.Targets cardiolipin in the inner mitochondrial membrane, stabilizing ATP production.Coenzyme essential for cellular energy production and sirtuin activity. Direct infusion or injection raises tissue levels.
Top outcomes
  • Longevity78
  • Sleep55
  • Inflammation70
  • Recovery60
  • Longevity55
  • Energy80
  • Longevity70
  • Fat loss60
  • Energy78
  • Longevity65
  • Energy78
  • Longevity72
  • Cognition55
Evidenceanecdotalestablishedemergingemergingemerging
Half-life~30 min (short; cycled dosing typical)~2 hoursSeveral hours~2-3 hoursVaries by route
Administrationsubqsubqsubqsubqsubq, im
Legal statusresearch onlyapproved some regionsresearch onlyresearch onlyapproved some regions
SafetyNo major adverse events reported in available literature.Very well tolerated. Mild injection-site reactions most common.Limited human safety data; well tolerated anecdotally.Well tolerated in trials.Injection can be uncomfortable (flushing, pressure). IV is well tolerated when titrated.
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