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α-MSH

Also: Alpha-Melanocyte Stimulating Hormone

Natural parent of melanotan-class peptides.

Evidence
emerging
Legal status
research only
Half-life
~2 minutes
Routes
subq
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What it is

α-MSH is the body's native MC1R/MC4R ligand. It's used in research as the canonical reference compound for melanotan-class effects.

Mechanism

Endogenous melanocortin receptor agonist driving pigmentation and appetite regulation.

Outcomes it's matched to
Safety

Flushing, nausea similar to MT-II.

  • Atypical naevi
  • Personal/family melanoma
Legal context

Research use only.

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