Argireline
Also: Acetyl Hexapeptide-3
Mild topical Botox-mimic — best for expression lines.
Evidence
established
Legal status
approved some regions
Half-life
n/a (topical)
Routes
topical
What it is
Argireline mimics the N-terminal of SNAP-25 and competitively reduces vesicle fusion, blunting facial muscle contraction strength.
Mechanism
Inhibits SNAP-25, reducing neurotransmitter release at the neuromuscular junction.
Outcomes it's matched to
- STRENGTH55%
Safety
Very well tolerated.
Legal context
Cosmetic ingredient.