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GHK-Cu

Also: Copper Peptide · Copper tripeptide-1

The original copper peptide — collagen, skin tone, hair density.

Evidence
emerging
Legal status
approved some regions
Half-life
Short systemically; topical action is local
Routes
topical · subq
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What it is

GHK-Cu is a naturally occurring copper-binding tripeptide whose plasma levels decline with age. It has been studied extensively for skin regeneration, hair follicle stimulation, and wound healing. Most commonly used topically; injectable use is more experimental.

Mechanism

Copper-binding tripeptide. Stimulates collagen, elastin, and antioxidant gene expression; supports wound healing.

Outcomes it's matched to
Safety

Very well tolerated topically. Mild local reaction possible with injection.

  • Copper sensitivity
Legal context

Permitted in cosmetics globally; injectable form is research-only.

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