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Dulaglutide

Also: Trulicity

Weekly GLP-1 with cardiovascular outcome data in T2D.

Evidence
established
Legal status
rx only
Half-life
~5 days
Routes
subq
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What it is

Dulaglutide is a fusion of two GLP-1 analogs to a human IgG4 Fc fragment, giving it a long half-life suitable for once-weekly dosing. Primarily approved for type 2 diabetes.

Mechanism

Long-acting GLP-1 fusion protein — weekly dosing.

Outcomes it's matched to
Safety

Nausea on titration; well-tolerated long term.

  • MTC history
  • MEN2
Legal context

FDA-approved for T2D.

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