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Liraglutide

Also: Saxenda · Victoza

The original FDA-approved daily GLP-1 for weight loss.

Evidence
established
Legal status
rx only
Half-life
~13 hours
Routes
subq
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What it is

Liraglutide was the first GLP-1 agonist approved for chronic weight management. Daily injection makes it more demanding than weekly semaglutide but the same mechanism applies.

Mechanism

Long-acting GLP-1 agonist that slows gastric emptying and reduces appetite.

Outcomes it's matched to
Safety

Nausea, GI upset on titration; pancreatitis warning; thyroid C-cell tumors in rodents.

  • MTC history
  • MEN2
  • Pregnancy
Legal context

FDA-approved (Saxenda/Victoza). Prescription required.

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