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Noopept

Also: N-phenylacetyl-L-prolylglycine ethyl ester

Russian-developed prescription nootropic with strong anecdotal cognitive reports.

Evidence
emerging
Legal status
research only
Half-life
~30 minutes (prodrug)
Routes
oral
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What it is

Noopept is a prodrug of cycloprolylglycine and is reported to enhance memory, focus, and recovery from neurological insult. Widely used as a research nootropic outside Russia.

Mechanism

Increases BDNF and NGF expression; modulates AMPA/NMDA glutamate signaling.

Outcomes it's matched to
Safety

Generally well tolerated; irritability and headaches reported.

  • Pregnancy
Legal context

Prescription compound in Russia; research use only in Western markets.

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