/ database / Melanocortin Agonist

Melanotan II

Also: MT-II · MT2

Stimulates melanin production for a deeper tan with less UV exposure.

Evidence
emerging
Legal status
grey market
Half-life
~33 hours
Routes
subq
What it is

Melanotan II activates MC1R receptors in melanocytes to produce a tan. It is the most-discussed tanning peptide, though it carries notable side effects (nausea, flushing, dark spots, mole changes) that demand caution. Dermatologist supervision is sensible.

Mechanism

Non-selective melanocortin receptor agonist. Stimulates melanin production (MC1R) and central arousal pathways (MC4R).

Outcomes it's matched to
Safety

Common side effects: nausea, facial flushing, darkening of moles, appetite suppression. Mole monitoring strongly advised.

  • History of melanoma or atypical nevi
  • Pregnancy
Legal context

Not approved. Sold as research compound in most regions.

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