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Sermorelin

Also: GRF 1-29

The original clinical GHRH analog — gentle, well-tolerated GH support.

Evidence
established
Legal status
rx only
Half-life
~10-20 minutes
Routes
subq
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What it is

Sermorelin is a 29-amino-acid fragment of native GHRH. It is FDA-approved for the diagnosis and treatment of GH deficiency in children and is widely used off-label in anti-aging clinics.

Mechanism

Truncated GHRH analog that stimulates pituitary GH release.

Outcomes it's matched to
Safety

Excellent safety profile across decades of clinical use.

  • Active malignancy
  • Pregnancy
Legal context

Prescription compound in the US; previously withdrawn but still available via compounding pharmacies.

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