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Spadin

Pre-clinical fast-acting antidepressant target.

Evidence
anecdotal
Legal status
research only
Half-life
~7 hours (rodent)
Routes
subq
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What it is

Spadin selectively blocks TREK-1 channels, producing antidepressant effects in mice within hours rather than weeks. No human safety data yet.

Mechanism

TREK-1 potassium channel antagonist — rapid antidepressant action in mice.

Outcomes it's matched to
Safety

Unknown in humans.

  • Without medical supervision
Legal context

Research use only. No human data.

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