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VIP

Also: Vasoactive Intestinal Peptide

Used off-label in CIRS/mold-illness protocols.

Evidence
emerging
Legal status
rx only
Half-life
~2 minutes (extended via nasal carrier)
Routes
nasal · subq
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What it is

VIP is most commonly discussed in chronic inflammatory response syndrome (CIRS) protocols. Clinical evidence outside that niche is limited.

Mechanism

Activates VPAC1/VPAC2 receptors with broad immunomodulatory and vasodilatory effects.

Outcomes it's matched to
Safety

Flushing, BP changes, GI effects possible.

  • Mast cell disease without supervision
Legal context

Compounded prescription in some US clinics.

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