SNAP-8
Also: Acetyl Octapeptide-3
Topical 'Botox-mimetic' peptide for expression-line softening.
Evidence
emerging
Legal status
approved some regions
Half-life
N/A (topical, repeated application)
Routes
topical
What it is
SNAP-8 is an extended analog of Argireline (Acetyl Hexapeptide-3). Both work by interfering with the SNARE complex that mediates acetylcholine release. SNAP-8 is marketed as having improved efficacy over Argireline at the same concentration, though independent comparative trials are limited.
Mechanism
Eight-amino-acid peptide that competes with the SNAP-25 protein in the SNARE complex, limiting neurotransmitter release at the neuromuscular junction in expression-line areas.
Outcomes it's matched to
- STRENGTH60%
Safety
Excellent topical safety. Effect is modest and requires consistent multi-week application.
Legal context
Cosmetic-grade ingredient. Permitted in topical formulations.